Molecular hydrogen alleviates asphyxia-induced neuronal cyclooxygenase-2 expression in newborn pigs
Cyclooxygenase-2 (COX-2) has an established role in the pathogenesis of hypoxic-ischemic encephalopathy (HIE). In this study we sought to determine whether COX-2 was induced by asphyxia in newborn pigs, and whether neuronal COX-2 levels were affected by H2 treatment. Piglets were subjected to either...
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| Dokumentumtípus: | Cikk |
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2018
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| Sorozat: | ACTA PHARMACOLOGICA SINICA
39 No. 8 |
| doi: | 10.1038/aps.2017.148 |
| mtmt: | 3393020 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/14829 |
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| 024 | 7 | |a 3393020 |2 mtmt | |
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| 100 | 1 | |a Varga Viktória Éva | |
| 245 | 1 | 0 | |a Molecular hydrogen alleviates asphyxia-induced neuronal cyclooxygenase-2 expression in newborn pigs |h [elektronikus dokumentum] / |c Varga Viktória Éva |
| 260 | |c 2018 | ||
| 300 | |a 1273-1283 | ||
| 490 | 0 | |a ACTA PHARMACOLOGICA SINICA |v 39 No. 8 | |
| 520 | 3 | |a Cyclooxygenase-2 (COX-2) has an established role in the pathogenesis of hypoxic-ischemic encephalopathy (HIE). In this study we sought to determine whether COX-2 was induced by asphyxia in newborn pigs, and whether neuronal COX-2 levels were affected by H2 treatment. Piglets were subjected to either 8 min of asphyxia or a more severe 20 min of asphyxia followed by H2 treatment (inhaling room air containing 2.1% H2 for 4 h). COX-2 immunohistochemistry was performed on brain samples from surviving piglets 24 h after asphyxia. The percentages of COX-2-immunopositive neurons were determined in cortical and subcortical areas. Only in piglets with more severe HIE, we observed significant, region-specific increases in neuronal COX-2 expression within the parietal and occipital cortices and in the CA3 hippocampal subfield. H2 treatment essentially prevented the increases in COX-2-immunopositive neurons. In the parietal cortex, the attenuation of COX-2 induction was associated with reduced 8'-hydroxy-2'-deoxyguanozine immunoreactivity and retained microglial ramifcation index, which are markers of oxidative stress and neuroin fl ammation, respectively. This study demonstrates for the first time that asphyxia elevates neuronal COX-2 expression in a piglet HIE model. Neuronal COX-2 induction may play region-specific roles in brain lesion progression during HIE development, and inhibition of this response may contribute to the antioxidant/anti-in fl ammatory neuroprotective effects of H2 treatment. | |
| 700 | 0 | 1 | |a Németh János |e aut |
| 700 | 0 | 1 | |a Oláh Orsolya |e aut |
| 700 | 0 | 2 | |a Tóth-Szűki Valéria |e aut |
| 700 | 0 | 2 | |a Kovács Viktória |e aut |
| 700 | 0 | 2 | |a Remzső Gábor |e aut |
| 700 | 0 | 2 | |a Domoki Ferenc |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/14829/1/Domoki_ActaPharmacolSin_2018.pdf |z Dokumentum-elérés |