Exploring jolkinol D derivatives to overcome multidrug resistance in cancer
Macrocyclic monoacyl lathyrane derivatives bearing a benzoyl moiety were previously found to be strong ABCB1 modulators. To explore the effects of different substituents of the aromatic moiety, 14 new compounds (1.1-1.7, 1.10, and 2.1-2.4) were prepared from jolkinol D (1), obtained from Euphorbia p...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2017
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| Sorozat: | JOURNAL OF NATURAL PRODUCTS
80 No. 5 |
| doi: | 10.1021/acs.jnatprod.6b01084 |
| mtmt: | 3227556 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/13630 |