The monocyte-to-lymphocyte ratio correlates with psycho-neuro-inflammatory factors in patients with stable coronary artery disease
BACKGROUND: Psychosocial stress and depression have been recognized as major risk factors of coronary artery disease (CAD). Although monocytes are known to be key players in atherosclerosis, monocyte-based associations with psychoneuroendocrino-immuno-inflammatory (PNI) markers have not been widely...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2016
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| Sorozat: | NEUROIMMUNOMODULATION
23 No. 2 |
| doi: | 10.1159/000443835 |
| mtmt: | 3078290 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/13610 |
| LEADER | 02934nab a2200277 i 4500 | ||
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| 001 | publ13610 | ||
| 005 | 20190325104447.0 | ||
| 008 | 180709s2016 hu o 0|| zxx d | ||
| 022 | |a 1021-7401 | ||
| 024 | 7 | |a 10.1159/000443835 |2 doi | |
| 024 | 7 | |a 3078290 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Serfőző Gyöngyi | |
| 245 | 1 | 4 | |a The monocyte-to-lymphocyte ratio correlates with psycho-neuro-inflammatory factors in patients with stable coronary artery disease |h [elektronikus dokumentum] / |c Serfőző Gyöngyi |
| 260 | |c 2016 | ||
| 300 | |a 67-74 | ||
| 490 | 0 | |a NEUROIMMUNOMODULATION |v 23 No. 2 | |
| 520 | 3 | |a BACKGROUND: Psychosocial stress and depression have been recognized as major risk factors of coronary artery disease (CAD). Although monocytes are known to be key players in atherosclerosis, monocyte-based associations with psychoneuroendocrino-immuno-inflammatory (PNI) markers have not been widely investigated in stable CAD. OBJECTIVE: We examined associations between the monocyte-to-lymphocyte ratio (MLR) and key PNI markers in stable CAD. METHODS: We studied 23 patients with stable CAD who completed the Beck Depression Inventory (BDI) and Rahe's Brief Stress and Coping Inventory. A white blood cell differential was performed, and levels of cortisol, chromogranin A (CgA), LL-37, interleukin-6 (IL-6) and C-reactive protein (CRP) were assayed in plasma. RESULTS: Monocyte fraction, MLR and plasma CgA levels exceeded reference values, the social support score was low, and 7 patients had elevated BDI scores. In the multivariate-adjusted analysis, a higher MLR was associated with greater depressive symptom severity (r = 0.624, p < 0.01) as well as with higher concentrations of CgA (r = 0.660, p < 0.01), LL-37 (r = 0.643, p < 0.01), IL-6 (r = 0.532, p < 0.05) and CRP (r = 0.470, p < 0.05). BDI scores associated with CgA concentration (r = 0.618, p < 0.01) and CgA level correlated negatively with the social support score (r = -0.511, p < 0.05). CONCLUSIONS: Our findings suggest that, in patients with stable CAD, elevated MLR may be associated with depressive symptoms, with increased neuroendocrine-sympathetic activity (marked by CgA) and inflammatory markers that are pertinent to atherosclerosis initiation and progression. The increased neuroendocrine-sympathetic activity correlated with low social support and depressive symptom severity. The MLR might serve as an easy-to-obtain and inexpensive proxy measure of an activated PNI network in stable CAD. | |
| 700 | 0 | 1 | |a Horváth Tamás |e aut |
| 700 | 0 | 1 | |a Földesi Imre |e aut |
| 700 | 0 | 2 | |a Bodóné Rafael Beatrix |e aut |
| 700 | 0 | 2 | |a von Känel Roland |e aut |
| 700 | 0 | 2 | |a Keresztes Margit |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/13610/1/Serfozo_et_al._2016_Neuroimmunomodulation_u.pdf |z Dokumentum-elérés |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/13610/7/447438.pdf |z Dokumentum-elérés |