Solid-phase synthesis of 6,7-cycloalkane-fused 1,4-diazepane-2,5-diones via a cyclization/release strategy
A solid-phase synthesis procedure for the parallel preparation of 6,7-cycloalkane-fused 1,4-diazepane-2,5-diones is described. The methodology applies alpha- and alicyclic beta-amino acid building blocks to construct the seven-membered heterocyclic core, while alcohols are used for further skeletal...
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2016
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| Sorozat: | TETRAHEDRON
72 No. 1 |
| doi: | 10.1016/j.tet.2015.11.023 |
| mtmt: | 3005721 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/12634 |
| LEADER | 01607nab a2200277 i 4500 | ||
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| 001 | publ12634 | ||
| 005 | 20200330162438.0 | ||
| 008 | 180108s2016 hu o 0|| zxx d | ||
| 022 | |a 0040-4020 | ||
| 024 | 7 | |a 10.1016/j.tet.2015.11.023 |2 doi | |
| 024 | 7 | |a 3005721 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Caroen Jurgen | |
| 245 | 1 | 0 | |a Solid-phase synthesis of 6,7-cycloalkane-fused 1,4-diazepane-2,5-diones via a cyclization/release strategy |h [elektronikus dokumentum] / |c Caroen Jurgen |
| 260 | |c 2016 | ||
| 300 | |a 148-160 | ||
| 490 | 0 | |a TETRAHEDRON |v 72 No. 1 | |
| 520 | 3 | |a A solid-phase synthesis procedure for the parallel preparation of 6,7-cycloalkane-fused 1,4-diazepane-2,5-diones is described. The methodology applies alpha- and alicyclic beta-amino acid building blocks to construct the seven-membered heterocyclic core, while alcohols are used for further skeletal decoration. The use of a cyclization/release strategy permits the isolation of the target cyclic alpha,beta-dipeptides in good crude purities and generally moderate to good yields. A 26-membered model library is reported and NMR spectroscopical data are used to describe the overall conformational behaviour of the obtained homodiketopiperazines. (C) 2015 Elsevier Ltd. All rights reserved. | |
| 700 | 0 | 1 | |a Clemmen An |e aut |
| 700 | 0 | 1 | |a Kámán Judit |e aut |
| 700 | 0 | 1 | |a Backaert Fréderique |e aut |
| 700 | 0 | 1 | |a Goeman Jan L. |e aut |
| 700 | 0 | 1 | |a Fülöp Ferenc |e aut |
| 700 | 0 | 2 | |a Van der Eycken Johan |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/12634/1/fulop_u.pdf |z Dokumentum-elérés |