Long-term outcome of combined (percutaneous intramyocardial and intracoronary) application of autologous bone marrow mononuclear cells post myocardial infarction the 5-year MYSTAR study /
OBJECTIVE: The long-term (5-year) outcome of early (3-6 weeks after acute myocardial infarction [AMI], BM-MNC Early group) and late (3-4 months after AMI, BM-MNC Late group) combined (percutaneous intramyocardial and intracoronary) delivery of autologous bone marrow mononuclear cells (BM-MNCs) was...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
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Public Library of Science (PLoS)
2016
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| Sorozat: | PLOS ONE
11 No. 10 |
| doi: | 10.1371/journal.pone.0164908 |
| mtmt: | 3174445 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/11861 |
| LEADER | 03208nab a2200373 i 4500 | ||
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| 022 | |a 1932-6203 | ||
| 024 | 7 | |a 10.1371/journal.pone.0164908 |2 doi | |
| 024 | 7 | |a 3174445 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Gyöngyösi Mariann | |
| 245 | 1 | 0 | |a Long-term outcome of combined (percutaneous intramyocardial and intracoronary) application of autologous bone marrow mononuclear cells post myocardial infarction |h [elektronikus dokumentum] : |b the 5-year MYSTAR study / |c Gyöngyösi Mariann |
| 260 | |a Public Library of Science (PLoS) |c 2016 | ||
| 300 | |a Terjedelem: 17 p-Azonosító: e0164908 | ||
| 490 | 0 | |a PLOS ONE |v 11 No. 10 | |
| 520 | 3 | |a OBJECTIVE: The long-term (5-year) outcome of early (3-6 weeks after acute myocardial infarction [AMI], BM-MNC Early group) and late (3-4 months after AMI, BM-MNC Late group) combined (percutaneous intramyocardial and intracoronary) delivery of autologous bone marrow mononuclear cells (BM-MNCs) was evaluated in patients with ejection fractions (EF) between 30-45% post-AMI. METHODS: Major adverse cardiac and cerebrovascular events (MACCE) and hospitalization were recorded. Left (LV) and right (RV) ventricular function were measured by transthoracic echocardiography. Cardiac magnetic resonance imaging (MRI) and myocardial single photon emission computed tomography was performed in a subgroup of patients. Pre-cell therapy myocardial voltage values of treated areas (assessed by NOGA mapping) were correlated with clinical outcome. RESULTS: Five-year MACCE incidences (7.4%. vs 24.1%) and the composite of all adverse events (11.1% vs 27.6%) were not different between the Early and Late treatment groups. The significant LV-EF increase at 1-year follow-up was preserved at the 5-year control (from baseline to 5-year: 5.3%, 95% CI:0.5-10.1, and 5.7%, 95% CI:1.7-9.6, p<0.05 in the Early and Late groups, respectively), with no significant changes between 1- and 5-year follow-ups. Similarly, RVEF increased significantly from baseline to the 5-year follow-up (Early group: 5.4%, 95% CI:1.0-9.6; and Late group: 8.4%, 95% CI:4.5-12.3). Lower baseline levels of myocardial viability of the treated cardiac area (6.3+/-2.4 vs 8.2+/-3.0 mV, p<0.05) were associated with incidence of MACCE. CONCLUSIONS: Percutaneous combined delivery of autologous BM-MNCs is feasible and safe after 5 years, and may result in sustained improvement of cardiac function at 5 years in patients with low EF post-AMI (Clinicaltrials.gov NCT01395212). | |
| 700 | 0 | 1 | |a Giurgea Georgiana-Aura |e aut |
| 700 | 0 | 1 | |a Syeda Bonni |e aut |
| 700 | 0 | 1 | |a Charwat Silvia |e aut |
| 700 | 0 | 1 | |a Marzluf Beatrice |e aut |
| 700 | 0 | 1 | |a Mascherbauer Julia |e aut |
| 700 | 0 | 1 | |a Jakab András |e aut |
| 700 | 0 | 1 | |a Zimba Abelina |e aut |
| 700 | 0 | 1 | |a Sárközy Márta |e aut |
| 700 | 0 | 1 | |a Pávó Noémi |e aut |
| 700 | 0 | 1 | |a Sochor Heinz |e aut |
| 700 | 0 | 1 | |a Graf Senta |e aut |
| 700 | 0 | 1 | |a Lang Irene |e aut |
| 700 | 0 | 1 | |a Maurer Gerald |e aut |
| 700 | 0 | 2 | |a Bergler-Klein Jutta |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/11861/1/journal.pone.0164908.PDF |z Dokumentum-elérés |