High-dose radiation induced heart damage in a rat model
BACKGROUND/AIM: Radiation-induced heart disease (RIHD) is a concern during radiotherapy. For its comprehensive study, an in vivo selective heart irradiation model was developed. MATERIALS AND METHODS: Sprague-Dawley rats were irradiated with 50 Gy and functional imaging, biochemical (circulating gro...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2016
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| Sorozat: | IN VIVO
30 No. 5 |
| mtmt: | 3105323 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/11798 |
| LEADER | 02153nab a2200337 i 4500 | ||
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| 005 | 20191203110418.0 | ||
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| 024 | 7 | |a 3105323 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Kiscsatári Laura | |
| 245 | 1 | 0 | |a High-dose radiation induced heart damage in a rat model |h [elektronikus dokumentum] / |c Kiscsatári Laura |
| 260 | |c 2016 | ||
| 300 | |a 623-631 | ||
| 490 | 0 | |a IN VIVO |v 30 No. 5 | |
| 520 | 3 | |a BACKGROUND/AIM: Radiation-induced heart disease (RIHD) is a concern during radiotherapy. For its comprehensive study, an in vivo selective heart irradiation model was developed. MATERIALS AND METHODS: Sprague-Dawley rats were irradiated with 50 Gy and functional imaging, biochemical (circulating growth differentiation factor-15 (GDF-15), transforming growth factor-beta (TGF-beta) and morphological (picrosirius red staining of the heart) objectives were tested. RESULTS: Signs and symptoms of RIHD occurred >12 weeks after irradiation with tachypnea, systolic and diastolic dysfunction, cardiac hypertrophy and body development retardation. Plasma GDF-15 was increased 3, 12 and 26, while plasma TGF-beta was increased 12 weeks after irradiation. At autopsy, extensive pleural fluid was found in the irradiated animals. Interstitial fibrosis could be reliably detected and quantified in irradiated hearts after a follow-up time of 19 weeks. CONCLUSION: The studied parameters could be used in future experiments for testing protective agents for prevention of radiation heart injury. | |
| 700 | 0 | 1 | |a Sárközy Márta |e aut |
| 700 | 0 | 1 | |a Kővári Bence |e aut |
| 700 | 0 | 1 | |a Varga Zoltán |e aut |
| 700 | 0 | 1 | |a Gömöri Kamilla |e aut |
| 700 | 0 | 1 | |a Morvay Nikolett |e aut |
| 700 | 0 | 1 | |a Leprán István |e aut |
| 700 | 0 | 1 | |a Hegyesi Hargita |e aut |
| 700 | 0 | 1 | |a Fábián Gabriella |e aut |
| 700 | 0 | 1 | |a Cserni Bálint |e aut |
| 700 | 0 | 1 | |a Cserni Gábor |e aut |
| 700 | 0 | 1 | |a Csont Tamás Bálint |e aut |
| 700 | 0 | 1 | |a Kahán Zsuzsanna |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/11798/1/Kiscsatari_InVivo_2016.pdf |z Dokumentum-elérés |