Cholinergic basal forebrain structures are involved in the mediation of the arousal effect of noradrenaline
Cholinergic basal forebrain structures are implicated in cortical arousal and regulation of the sleep-wake cycle. Cholinergic neurones are innervated by noradrenergic terminals, noradrenaline excites them via alpha-1 receptors and microinjection of noradrenaline into the basal forebrain enhances wak...
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2013
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| Sorozat: | JOURNAL OF SLEEP RESEARCH
22 No. 6 |
| doi: | 10.1111/jsr.12061 |
| mtmt: | 2497631 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/11381 |
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| 024 | 7 | |a 2497631 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
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| 100 | 1 | |a Lelkes Zoltán | |
| 245 | 1 | 0 | |a Cholinergic basal forebrain structures are involved in the mediation of the arousal effect of noradrenaline |h [elektronikus dokumentum] / |c Lelkes Zoltán |
| 260 | |c 2013 | ||
| 300 | |a 721-726 | ||
| 490 | 0 | |a JOURNAL OF SLEEP RESEARCH |v 22 No. 6 | |
| 520 | 3 | |a Cholinergic basal forebrain structures are implicated in cortical arousal and regulation of the sleep-wake cycle. Cholinergic neurones are innervated by noradrenergic terminals, noradrenaline excites them via alpha-1 receptors and microinjection of noradrenaline into the basal forebrain enhances wakefulness. However, it is not known to what extent the cholinergic versus non-cholinergic basal forebrain projection neurones contribute to the arousing effects of noradrenaline. To elucidate the roles of cholinergic basal forebrain structures we administered methoxamine, an alpha-1-adrenergic agonist into the basal forebrain, in intact animals and again after selective destruction of the basal forebrain cholinergic cells by 192 IgG-saporin. In eight male Han-Wistar rats implanted with electroencephalogram/electromyogram electrodes, a microdialysis probe targeted into the basal forebrain was perfused with artificial cerebrospinal fluid for 6 h on a baseline day, and with cerebrospinal fluid in the first and with methoxamine in the second 3-h period of the subsequent day. The sleep-wake activity was recorded for 24 h on both days. Saporin was then injected into the basal forebrain and 2 weeks later the same experimental schedule (with cerebrospinal fluid and methoxamine) was repeated. In the intact animals, methoxamine exhibited a robust arousing effect and non-rapid eye movement (NREM) and REM sleep was suppressed. Lesioning of the basal forebrain cholinergic neurones abolished almost completely the NREM sleep-suppressing effect of methoxamine, whereas the REM sleep-suppressing effect remained intact. Thus, the basal forebrain cholinergic neurones mediate, at least in part, cortical arousal and non-REM sleep-suppression, but they are not involved in the REM sleep-suppressing effects of noradrenaline. | |
| 700 | 0 | 2 | |a Porkka-Heiskanen Tarja |e aut |
| 700 | 0 | 2 | |a Stenberg Dag |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/11381/1/Lelkes_jsr_2013.pdf |z Dokumentum-elérés |