Neural substrates and potential treatments for levodopa-induced dyskinesias in Parkinson's disease
Parkinson's disease (PD) is primarily a motor disorder that involves the gradual loss of motor function. Symptoms are observed initially in the extremities, such as hands and arms, while advanced stages of the disease can effect blinking, swallowing, speaking, and breathing. PD is a neurodege...
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2016
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| Sorozat: | REVIEWS IN THE NEUROSCIENCES
27 No. 7 |
| doi: | 10.1515/revneuro-2016-0009 |
| mtmt: | 3092623 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/11336 |
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| 024 | 7 | |a 3092623 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Phillips Joseph R. | |
| 245 | 1 | 0 | |a Neural substrates and potential treatments for levodopa-induced dyskinesias in Parkinson's disease |h [elektronikus dokumentum] / |c Phillips Joseph R. |
| 260 | |c 2016 | ||
| 300 | |a 729-738 | ||
| 490 | 0 | |a REVIEWS IN THE NEUROSCIENCES |v 27 No. 7 | |
| 520 | 3 | |a Parkinson's disease (PD) is primarily a motor disorder that involves the gradual loss of motor function. Symptoms are observed initially in the extremities, such as hands and arms, while advanced stages of the disease can effect blinking, swallowing, speaking, and breathing. PD is a neurodegenerative disease, with dopaminergic neuronal loss occurring in the substantia nigra pars compacta, thus disrupting basal ganglia functions. This leads to downstream effects on other neurotransmitter systems such as glutamate, gamma-aminobutyric acid, and serotonin. To date, one of the main treatments for PD is levodopa. While it is generally very effective, prolonged treatments lead to levodopa-induced dyskinesia (LID). LID encompasses a family of symptoms ranging from uncontrolled repetitive movements to sustained muscle contractions. In many cases, the symptoms of LID can cause more grief than PD itself. The purpose of this review is to discuss the possible clinical features, cognitive correlates, neural substrates, as well as potential psychopharmacological and surgical (including nondopaminergic and deep brain stimulation) treatments of LID. | |
| 700 | 0 | 1 | |a Eissa Abeer M. |e aut |
| 700 | 0 | 1 | |a Hewedi Doaa H. |e aut |
| 700 | 0 | 1 | |a Jahanshahi Marjan |e aut |
| 700 | 0 | 2 | |a El-Gamal Mohamed |e aut |
| 700 | 0 | 2 | |a Kéri Szabolcs |e aut |
| 700 | 0 | 2 | |a Moustafa Ahmed A. |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/11336/1/Phillips_Moustafa_PD_levodopa_induced_dyskinesia_2016_u.pdf |z Dokumentum-elérés |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/11336/7/Reviews%20in%20the%20Neurosciences_tartj.pdf |z Dokumentum-elérés |