Depletion of calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat after electrical stimulation of the Gasserian ganglion

Electrical stimulation of the Gasserian ganglion resulted in partial depletion of calcitonin gene-related peptide (CGRP) from ipsilateral central terminals of pseudounipolar primary sensory ganglion cells. Affected terminals exhibit decreased CGRP immunoreactivity as shown by cytophotometric densito...

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Elmentve itt :
Bibliográfiai részletek
Szerzők: Knyihár-Csillik Erzsébet
Tajti János
Samsam Mohtasham
Sáry Gyula
Buzás Péter
Vécsei László
Dokumentumtípus: Cikk
Megjelent: Springer 1998
Sorozat:EXPERIMENTAL BRAIN RESEARCH 118 No. 1
doi:10.1007/s002210050260

mtmt:1032267
Online Access:http://publicatio.bibl.u-szeged.hu/10543
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520 3 |a Electrical stimulation of the Gasserian ganglion resulted in partial depletion of calcitonin gene-related peptide (CGRP) from ipsilateral central terminals of pseudounipolar primary sensory ganglion cells. Affected terminals exhibit decreased CGRP immunoreactivity as shown by cytophotometric densitometry of the caudal trigeminal nucleus. The decrease in CGRP immunoreactivity is statistically significant only in the medial one-third of the caudal trigeminal nucleus. Since earlier studies have shown that electrical stimulation of the Gasserian ganglion induces first accumulation then depletion of CGRP from perivascular sensory terminals in the dura mater, the present experiments suggest that CGRP is depleted also from central terminals of primary sensory trigeminal neurons, which might be of importance in the pathogenesis of migraine headache. 
700 0 1 |a Tajti János  |e aut 
700 0 1 |a Samsam Mohtasham  |e aut 
700 0 1 |a Sáry Gyula  |e aut 
700 0 1 |a Buzás Péter  |e aut 
700 0 1 |a Vécsei László  |e aut 
856 4 0 |u http://publicatio.bibl.u-szeged.hu/10543/1/Knyihar_E._Gasserian_ganglion_u.pdf  |z Dokumentum-elérés