An engineered scorpion toxin analogue with improved Kv1.3 selectivity displays reduced conformational flexibility
The voltage-gated Kv1.3 K(+) channel plays a key role in the activation of T lymphocytes. Kv1.3 blockers selectively suppress immune responses mediated by effector memory T cells, which indicates the great potential of selective Kv1.3 inhibitors in the therapy of certain autoimmune diseases. Anuroct...
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| Dokumentumtípus: | Cikk |
| Megjelent: |
Nature Publishing Group
2015
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| Sorozat: | SCIENTIFIC REPORTS
5 |
| doi: | 10.1038/srep18397 |
| mtmt: | 2989144 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/10460 |