%0 Article %A Benedek György %D 2008 %C Wiley %G No linguistic content %B EUROPEAN JOURNAL OF ORGANIC CHEMISTRY %@ 1434-193X %T Efficient synthesis of hydroxy-substituted cispentacin derivatives %U http://publicatio.bibl.u-szeged.hu/10394/1/Benedek_et_al_2008_European_Journal_of_Organic_Chemistry_u.pdf %X Starting from N-protected cis-and trans-2-aminocyclopent-3-enecarboxylic acid derivatives, isomers of 2-amino-3-hydroxycyclopentanecarboxylic acid (8 and 12) were prepared via oxazoline intermediates, whereas the stereoisomeric 2-amino-3,4-dihydroxycyclopentanecarboxylic acids 14 and 17 were synthesized by OsO4-catalyzed oxidation. The enantiomers of 8 and 14 were also prepared by the same pathway. The structures, stereochemistry and relative configurations of the synthesized compounds were proved by NMR spectroscopy. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).