Synthesis of bile acid amines via microwave irradiation

Herein, we present microwave-assisted reductive amination of oxo derivative of deoxycholic acid with morpholine in the presence of sodium-cyanoborohydride. These chemical transformation produces a majority of the 3β-amino isomer 5 as a new compound after five minutes of irradiation. In addition, for...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Vasiljević Bojana
Prekodravac Jovana
Jovanovic Dragana
Testületi szerző: International Symposium on Analytical and Environmental Problems (26.) (2020) (Szeged)
Dokumentumtípus: Könyv része
Megjelent: 2020
Sorozat:Proceedings of the International Symposium on Analytical and Environmental Problems 26
Kulcsszavak:Kémia
Tárgyszavak:
Online Access:http://acta.bibl.u-szeged.hu/74034
Leíró adatok
Tartalmi kivonat:Herein, we present microwave-assisted reductive amination of oxo derivative of deoxycholic acid with morpholine in the presence of sodium-cyanoborohydride. These chemical transformation produces a majority of the 3β-amino isomer 5 as a new compound after five minutes of irradiation. In addition, formylated bile acid have been proved as excellent starting material for the synthesis of bile acid`s N-morpholino amine. Microwave-assisted reactions of formylation in the absence of catalyst, selective deformylation, as well as further oxidation with N-bromosuccinimide gained 3-oxo derivatives of deoxycholic acid acid in high yield. Compared to the conventional protocol a remarkable reduction in overall processing time from hours to a few minutes was achieved.
Terjedelem/Fizikai jellemzők:344-348
ISBN:978-963-306-771-0