Transition metal-catalyzed synthesis of 13α-estrone derivatives with potential anticancer properties
Synthesis of 3-(N,N-dimethylcarbamoyl)-13α-estrone and its 17-deoxy counterpart has been carried out. The dimethylcarbamoyl directing group enabled the regioselective ortho arylation of the steroidal starting compounds. The microwave-assisted, palladium-catalyzed phenylations led to 2-substituted 13...
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| Dokumentumtípus: | Könyv része |
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2020
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| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
26 |
| Kulcsszavak: | Gyógyszerkémia, Analitikai kémia |
| Tárgyszavak: | |
| Online Access: | http://acta.bibl.u-szeged.hu/74032 |
| LEADER | 01761naa a2200289 i 4500 | ||
|---|---|---|---|
| 001 | acta74032 | ||
| 005 | 20220808153933.0 | ||
| 008 | 211118s2020 hu o 1|| eng d | ||
| 020 | |a 978-963-306-771-0 | ||
| 040 | |a SZTE Egyetemi Kiadványok Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Traj Péter | |
| 245 | 1 | 0 | |a Transition metal-catalyzed synthesis of 13α-estrone derivatives with potential anticancer properties |h [elektronikus dokumentum] / |c Traj Péter |
| 260 | |c 2020 | ||
| 300 | |a 338-341 | ||
| 490 | 0 | |a Proceedings of the International Symposium on Analytical and Environmental Problems |v 26 | |
| 520 | 3 | |a Synthesis of 3-(N,N-dimethylcarbamoyl)-13α-estrone and its 17-deoxy counterpart has been carried out. The dimethylcarbamoyl directing group enabled the regioselective ortho arylation of the steroidal starting compounds. The microwave-assisted, palladium-catalyzed phenylations led to 2-substituted 13α-estrones in a one-pot, tandem process. The Suzuki-Miyaura cross coupling reactions of the carbamates with phenylboronic acid resulted in 3-phenyl-3-deoxy13α-estrone. Certain newly synthesized compounds displayed potent antiproliferative action against human reproductive cancer cell lines of gynecological origin. | |
| 650 | 4 | |a Természettudományok | |
| 650 | 4 | |a Kémiai tudományok | |
| 695 | |a Gyógyszerkémia, Analitikai kémia | ||
| 700 | 0 | 1 | |a Abdolkhaliq Ali Hazhmat |e aut |
| 700 | 0 | 1 | |a Németh Anett |e aut |
| 700 | 0 | 1 | |a Dajcs Sámuel Trisztán |e aut |
| 700 | 0 | 1 | |a Zupkó István |e aut |
| 700 | 0 | 1 | |a Mernyák Erzsébet |e aut |
| 710 | |a International Symposium on Analytical and Environmental Problems (26.) (2020) (Szeged) | ||
| 856 | 4 | 0 | |u http://acta.bibl.u-szeged.hu/74032/1/proceedings_of_isaep_2020_338-341.pdf |z Dokumentum-elérés |