Synthesis and characterization of some potential biologically active niclosamide derivatives
Compounds with 2-hydroxy-benzanilide core are recognized for their biological effects. Niclosamide, in particular, is authorized for its anti-helmintic properties and, recently, demonstrated additional effects like antitumoral and antiviral ones. Thus, we considered worthwhile to synthesize some nic...
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| Dokumentumtípus: | Könyv része |
| Megjelent: |
2015
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| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
21 |
| Kulcsszavak: | Biokémia, Elektrokémia, Kémia |
| Online Access: | http://acta.bibl.u-szeged.hu/55953 |
| LEADER | 01792naa a2200253 i 4500 | ||
|---|---|---|---|
| 001 | acta55953 | ||
| 005 | 20220808154741.0 | ||
| 008 | 181205s2015 hu o 1|| zxx d | ||
| 020 | |a 978-963-306-411-5 | ||
| 040 | |a SZTE Egyetemi Kiadványok Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Ienaşcu Ioana M. C. | |
| 245 | 1 | 0 | |a Synthesis and characterization of some potential biologically active niclosamide derivatives |h [elektronikus dokumentum] / |c Ienaşcu Ioana M. C. |
| 260 | |c 2015 | ||
| 300 | |a 168-171 | ||
| 490 | 0 | |a Proceedings of the International Symposium on Analytical and Environmental Problems |v 21 | |
| 520 | 3 | |a Compounds with 2-hydroxy-benzanilide core are recognized for their biological effects. Niclosamide, in particular, is authorized for its anti-helmintic properties and, recently, demonstrated additional effects like antitumoral and antiviral ones. Thus, we considered worthwhile to synthesize some niclosamide derivatives, which could possess enhanced biological activity. Starting from 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide and methyl/ethyl α-halogenated acid esters were obtained methyl/ethyl esters. In order to prove the structural identity of the newly synthesized compounds, modern physico-chemical methods (FTIR, 1H-NMR, 13C-NMR) were used. The data obtained for the analyzed compounds proved their identity and confirm their structure. | |
| 695 | |a Biokémia, Elektrokémia, Kémia | ||
| 700 | 0 | 1 | |a Căta Adina |e aut |
| 700 | 0 | 1 | |a Ștefănuț Mariana Nela |e aut |
| 700 | 0 | 1 | |a Tănasie Cristian |e aut |
| 700 | 0 | 1 | |a Popescu Iuliana M. |e aut |
| 710 | |a International Symposium on Analytical and Environmental Problems (21.) (2015) (Szeged) | ||
| 856 | 4 | 0 | |u http://acta.bibl.u-szeged.hu/55953/1/proceedings_of_isaep_2015_168-171.pdf |z Dokumentum-elérés |