Retention and lipophilicity of newly synthesized 3-benzyloxy steroid derivatives in normal- and reversed-phase HPLC
The retention behaviour and separation ability of nine newly synthesized 3-benzyloxy estrone derivatives were studied by FIPLC on silica and C-18 commercially available columns. The mobile phases used were: benzene-ethyl acetate, benzene-tetrahydrofuran, benzene-acetonitrile, methanolwaler and aceto...
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| Format: | Article |
| Published: |
2012
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| Series: | Review of faculty of engineering : analecta technica Szegedinensia
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| Kulcsszavak: | Mérnöki tudományok, Kémia |
| Online Access: | http://acta.bibl.u-szeged.hu/11909 |
| Summary: | The retention behaviour and separation ability of nine newly synthesized 3-benzyloxy estrone derivatives were studied by FIPLC on silica and C-18 commercially available columns. The mobile phases used were: benzene-ethyl acetate, benzene-tetrahydrofuran, benzene-acetonitrile, methanolwaler and acetonitrilc-water in various proportions. The results are discussed in terms of nature of the solute, eluent and stationary phase. The correlation between the retention constants of nine 3- benzyloxy estrone derivatives obtained on C-18 column and calculated log P was examined too. |
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| Physical Description: | 6-15 |
| ISSN: | 1788-6392 |